Interpretation of the difference index as a guide to protein sequence identity

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Interpretation of the difference index as a guide to protein sequence identity.

The expected behaviour of the “difference index” (Metzger, Shapiro, Mosimann & Vinton, 1968) has been examined under simple assumptions. Provided that it is only used to compare the compositions of proteins of equal or near-equal length, it can be interpreted to provide an estimate of the number of differences between the two sequences. Results with several pairs of proteins are in good agreeme...

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ژورنال

عنوان ژورنال: Journal of Theoretical Biology

سال: 1978

ISSN: 0022-5193

DOI: 10.1016/0022-5193(78)90068-1